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SelectNodes Always returning the 0 count

SelectNodes always returning the 0 count even the it has the value.
<?xml version="1.0" encoding="utf-16"?>
<Configurations xmlns="DEH_Common.Schemas">
<sftpConfiguration>
<file>
<filedetails>
<fileext>csv</fileext>
<DataContentDetailId>1</DataContentDetailId>
</filedetails>
</file>
</sftpConfiguration>
</Configurations>
C# to read the nodelist....
XmlNodeList nodeList = xmlDoc.DocumentElement.SelectNodes("//Configurations/sftpConfiguration/file");

It's because of using namespace in your xml, You should add namespace to xmlDoc and also no need to useDocumentElement` This code would be work:
var nsmgr = new XmlNamespaceManager(xmlDoc.NameTable);
nsmgr.AddNamespace("a", "DEH_Common.Schemas");
XmlNodeList nodeList = xmlDoc.SelectNodes("//a:sftpConfiguration/a:file", nsmgr);

In your XML DocumentElement is the Configurations node, so your XPath should be sftpConfiguration/file
XmlNodeList nodeList = xmlDoc.DocumentElement.SelectNodes("sftpConfiguration/file");

Try this:
xmlDoc.DocumentElement.SelectNodes("/Configurations[#*]/sftpConfiguration/file");

How can I parse the following xml in c#

I need some help on how to get values of English and studentId from this XML. Maybe it needs some special parsing I can't figure out at the moment.
<?xml version="1.0" encoding="utf-8"?>
<soap:Envelope xmlns:soap="http://schemas.xmlsoap.org/soap/envelope/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema">
<soap:Body>
<processResponse xmlns="http://tempuri.org/">
<processResult>
<xml version="1.0" encoding="UTF-8"?>
<returnedResponse>
<English>94</English>
<Remarks>Excellent</Remarks>
<studentId>tst005</studentId>
<Department>6</Department>
</returnedResponse>
</processResult>
</processResponse>
</soap:Body>
</soap:Envelope>
I have tried the following code:
XmlDocument xdr = new XmlDocument();
xdr.LoadXml(thexml);
XmlNodeList nodelist = xdr.SelectNodes("//processResponse/processResult/returnedResponse");
foreach (XmlNode node in nodelist)
{
string eng = node.SelectSingleNode("English").InnerText;
Response.Write("eng");
}

Do you get an error with invalid XML or does your SelectNodes not find anything?
How about this path
XmlNodeList nodelist = xdr.SelectNodes("/*/*/*/processResponse/processResult/returnedResponse");

You can try with SelectSingleNode, just like this.
var English= xdr.DocumentElement.SelectSingleNode("English").InnerText;
var studentId = xdr.DocumentElement.SelectSingleNode("studentId").InnerText;

1) XML ist invalid at line 6 -> because it does not have a closing tag. If you cannot edit the Service and strip the xml header or encode the resulting xml, you have to strip the line 6 in you consumercode.
2) You have to define the Namespaces!
Btw: I highly recommend using (Linq2XML) XDocument. Your code could look like this:
XDocument xdr = XDocument.Parse(...);
var nodes = xdr.XPathSelectElements("//*[name()='returnedResponse']");

Try this
XmlDocument doc = new XmlDocument();
doc.LoadXml(xmlString);
XmlNodeList nList = doc.GetElementsByTagName("returnedResponse");
foreach (XmlNode node in nList)
{
XElement xelement = XElement.Parse(node.OuterXml);
var Descendents = xelement.Descendants();
foreach (var item in Descendents)
{
//you'll get each of your descendents here
}
}

Child nodes not accepted

I'm writing on a program in C# that'll take data from a server, write it into a file and then read the file to grab the data contained.
The last part is the problem. I get my XML-file stream and the XML file seems to be fine but except for the root node, my program doesn't accept any child nodes even though in a list it counts all the 700 child nodes. Was checking my spelling, the adressing, the tree... nothing worked so far.
XML Data:
<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/support/docs/uniprot.xsd">
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2013-10-16" version="51">
<accession>P69430</accession>
<accession>O65938</accession>
<accession>P27856</accession>
<name>TATA_ECO57</name>
<protein>
<recommendedName>
<fullName>Sec-independent protein translocase protein TatA</fullName>
</recommendedName>
</protein>
program:
Datapath = startupPath + "\\" + Data[0, 0] + ".xml";
XmlDocument XMLdoc = new XmlDocument();
XMLdoc.Load(Datapath);
XmlNodeList xnList = XMLdoc.SelectNodes("//*"); //the list shows all 700 entries so the path etc are correct
var node = XMLdoc.SelectSingleNode("uniprot/entry/protein/recommendedName/fullName").InnerText;
As soon as I try to adress any child node from uniprot, it's just null which drives me mad. Anyone can help please?

Have you tried using the namespace?
XmlDocument doc = new XmlDocument();
XmlNamespaceManager nsmgr = new XmlNamespaceManager(doc.NameTable);
nsmgr.AddNamespace("ns", "http://uniprot.org/uniprot");
var node = doc.SelectSingleNode("//ns:exampleNode", nsmgr);

Try this one: XmlNode node = doc.SelectSingleNode("//uniprot//entry/protein/recommendedName /fullName");
node.InnerXml;

How do I modify xml internal attributes

I am trying to edit a xml file.
XmlDocument myXmlDocument = new XmlDocument();
myXmlDocument.Load(#"C:\\Users\\Vahid\\Desktop\\HG\\HG\\HG\\singleM.kml");
XmlNode myNode = myXmlDocument.SelectSingleNode(
"/kml/Document/Placemark/Point/coordinates");
myNode.Value = coordinates;
myXmlDocument.Save(#"C:\\Users\\Vahid\\Desktop\\HG\\HG\\HG\\singleM.kml");
and this is my xml (.kml) file:
<?xml version="1.0" encoding="UTF-8"?>
<kml xmlns="http://www.opengis.net/kml/2.2" xmlns:gx="http://www.google.com/kml/ext/2.2"
xmlns:kml="http://www.opengis.net/kml/2.2" xmlns:atom="http://www.w3.org/2005/Atom">
<Document>
<name>change.kml</name>
<Style id="sn_ylw-pushpin"></Style>
<Placemark>
<Point>
<coordinates>0, 0,0</coordinates>
</Point>
<name>12</name>
</Placemark>
</Document>
</kml>

Xml namespaces:
XmlNamespaceManager ns = new XmlNamespaceManager(myXmlDocument.NameTable);
ns.AddNamespace("kml", "http://www.opengis.net/kml/2.2");
XmlNode myNode = myXmlDocument.SelectSingleNode("/kml:kml/kml:Document/kml:Placemark/kml:Point/kml:coordinates", ns);
myNode.InnerText = coordinates;
Note that there is nothing special about "kml" / "kml:" here - it could just as well be:
XmlNamespaceManager ns = new XmlNamespaceManager(myXmlDocument.NameTable);
ns.AddNamespace("x", "http://www.opengis.net/kml/2.2");
XmlNode myNode = myXmlDocument.SelectSingleNode("/x:kml/x:Document/x:Placemark/x:Point/x:coordinates", ns);
myNode.InnerText = coordinates;
The important point is that each of your elements are in the namespace http://www.opengis.net/kml/2.2; the AddNamespace is just adding an alias for that, so that we can talk about the namespace conveniently - we then write the xpath using the alias, and pass the namespace-manager to the SelectSingleNode methods.

Reading Elements within a Namespace

I have an XML file that looks like:
<?xml version="1.0" encoding="UTF-8"?>
<?xml-stylesheet type="text/xsl" href="https://www.someurl.com/somefile.xslt"?>
<AutoInsuranceClaim xmlns="http://www.someurl.com/schemas/AutoInsuranceClaim">
<Identification>
<BaseOwner>3</BaseOwner>
<BaseType>ABC123</BaseType>
<BaseTypeRef>471038341757</BaseTypeRef>
</Identification>
</AutoInsuranceClaim>
and I'm trying to read the Identification node. Here's my code:
XmlDocument xmlDoc = new XmlDocument();
xmlDoc.Load(#"..\..\Data.xml");
XmlNamespaceManager nsmgr = new XmlNamespaceManager(xmlDoc.NameTable);
nsmgr.AddNamespace("ns", "http://www.someurl.com/schemas/AutoInsuranceClaim");
XmlNodeList nodeList = xmlDoc.SelectNodes(#"/ns:AutoInsuranceClaim/Identification", nsmgr);
Console.WriteLine("There are {0} nodes...", nodeList.Count);
I know I should get a least 1 value. My understanding of .NET XML parsing is that if you have a default namespace with no prefix, you have to create your own namespace. But this should have returned 1.
If not, what am I missing?

I might be grasping at straws here, but shouldn't you be namespacing both entities in your xpath expression?
XmlNodeList nodeList = xmlDoc.SelectNodes(#"/ns:AutoInsuranceClaim/ns:Identification", nsmgr);

XElement root = XElement.Load("Data.xml");
var identifications = root.Descendants()
.Where(x => x.Name.LocalName == "Identification")
.ToList()

The problem is that you're trying to find an Identification node without a namespace, but it will have defaulted to the same namespace as the parent due to the xmlns=... part. Try this:
var nodeList = xmlDoc.SelectNodes("/ns:AutoInsuranceClaim/ns:Identification",
nsmgr);
Having tried it myself, it printed a count of 1.
Personally I'd use LINQ to XML instead though, which makes namespace easier handling:
XDocument doc = XDocument.Load(#"..\..\Data.xml");
XNamespace ns = "http://www.someurl.com/schemas/AutoInsuranceClaim";
var nodes = doc.Root.Elements(ns + "Identification");