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Black in my picturebox c#

when I use an image to a URL in my picture box I have black in here
Image = http://prntscr.com/cx1nre
I am known it's because my panel is on Highlight but when I use " Transparent " it give me a black in my picture box... example = http://prntscr.com/cwu9ev
Anyone can help me please?

After understanding your question (one picture over other and the top with transparency), your problem is how .net transparency works, it's not real transparency, it copies the background of the container.
So, to make it work instead of two picture boxes add a panel and a picturebox inside the panel, set the backgroundimage of the panel to the image you wanted to use, and then set the overlay image on the picturebox. As .net copies the container's backgrond, as you added the picture box as a child of the panel the picture box will copy the image and the transparency would work as you expected.
Only caveat is that you need to load manually the image, but there are plenty of examples on how to load it.
Also, there's even a better approach: instead of two pictureboxes just add one, load into a Bitmap the background you want, retrieve a Graphics object from it, draw the second image with Graphics.DrawImage and then use the bitmap as the Image for the picturebox. It's more complicated but it's the most efficient way to do this.

Transparency over multiple pictureBoxes

I have an array of picture boxes that are arranged in a square. I want to put a larger, mostly transparent picture box over the top. But when I do it covers the other picture boxes and just draws the background of the form.
Is there a way to get it to have all the other picture boxes show where it is transparent?

Transparency in WinForms isn't great. Some controls have transparency support, others don't. Some controls can be subclassed to enable this (by calling Control.SetStyle() with the SupportsTransparency flag). I believe this can be done with PictureBox.
However, transparency in all WinForms controls works by having the transparent control call its parent control to draw the background before the child control draws. This means that you cannot have two sibling controls and expect transparency on one to show through to the other. Sorry!
All that said, it would be possible to code your own workaround to support this. It would involve subclassing PictureBox and clever coding in the OnPaint override to locate sibling controls and manually trigger painting of them into in-memory bitmaps. Lots of gotchas with this approach.
Try WPF!

Here's a tip to get the desired result:
Create multiple copies of your top image.
Add each copy to the Controls of each picture box it should cover.
Adjust location of each copy according to the offset of each picture box to be covered.
So you will see every copy of your big image covering each picture box as if they were a single image.

Create Animated Button

I have button it possible create animate on click?
with photoshop i have created a two image (enabled and disabled). Insert the picturebox in Windows Forms and Click event..Click the image changes from enabled to disabled, but you can have an animation?
Like this:

It looks like you mentioned WinForms so I'll address that. Yes animation is possible but in general it's going to be a bit of work.
There appears to be an implementation of a general purpose animation framework (although limited) over on CodeProject. In the comments schallos posted a better implementation of the reflection code using expression trees.
The general principle is:
Use a PictureBox so you get double buffering
Use a timer control to control repainting (calling Invalidate() on your PictureBox)
You'll probably want to add some easing into the animation so it appears smoother; a bit of acceleration added to it when the user clicks goes a long way.

A timer is not required using a GIF.
Using windows forms you could start by creating an animated GIF for each button. It would have to include both the forward and backwards direction. You can do this through Photoshop via the "Animation" panel. On the PictureBox click event you can set the image to play or stop.
The code below would set your image on the beginning frame.
imgButtonDimension = new FrameDimension(imgButtonDimension.FrameDimensionsList[0]);
imgButton.SelectActiveFrame(imgButtonDimension, 0);
pictureBox.Image = imgButton;`
If this is the approach you'd like to take I can provide further elaboration.

How to make "mouse-transparent" panel?

I'm new to WPF so I've got a problem:
I need to create a grid. This grid should contain a column with a kind of thumbnails.
When I move mouse over a thumbnail, there should appear a panel with a big image. This panel will cover all grid.
But this will make thumbnail think that mouse already has gone.
After mouse's gone, panel should dissappear. Mouse appears above thumb again, and panel appears. And again, and again. I don't know how to handle this.
Could anybody suggest any solution?

Sounds to me like you want to use IsHitTestVisible="False" on the image that pops up. This will make it ignore the popup when testing where the mouse is, so it will think your mouse is still over the thumbnail image. This should work on any UI element, except windows.

Use MouseEnter and MouseLeave:
http://www.hanselman.com/blog/MouseEnterAndMouseLeaveLoopsInWPF.aspx

There are two ways I can think of to do this, depending on what kind of functionality you're looking for.
If you want the larger image to appear in proximity to the mouse and the thumbnail, then you might want to take a look at using a Tooltip.
Otherwise as Aliostad mentioned above, you could use the MouseEnter and MouseLeave events to trigger the display of whatever content is needed.

C# winforms Picturebox, backgroundimage zoomed at the top?

I have a picturebox where I change the BackgroundImage frequently. I have a the BackgroundImageLayout set to Zoom.
The problem is that when an image does not have the same scale as the picturebox, the picture is drawn in the middle. That is, the top and the bottom padding of the picturebox is always the same.
I would like for the BackgroundImage to always be aligned at the top. What is the easiest and most performance efficient way of doing this?
I can add that I download the images from the internet. If you think that the best way to deal with this is to resize them at that point I can do that :)

By far the simplest solution is to just change the Size property of the picture box so that the image can be drawn without padding. Implementing your own Paint event handler is possible too, not exactly necessary here I presume.